The area where Mineral de Pozos is located did not have important settlements, it was inhabited by Chichimecas nomadic tribes, huachichiles, copuces, guaxabanes and pames.
The European presence in the area occured until the year 1576 when the first Jesuits arrive to evangelize the local population. At that time the area was named Palmar de Vega.
In 1590 the viceroy Don Luis de Velasco and Castile, sent Gonzalo de Tapia, missionary of the Company of Jesus to subdue the local population.He spoke both language and knew about local customs. He was the founder of the Parish of San Luis Rey.
After living two years between them he managed to convince them to convert to Catholicism and subjugated to the Spanish crown. In this way the pacification and the consequent Spanish dominion was definitively consolidated.
Once the independence was consummated, President Santa Ana decreed the "Federal Territory of the Sierra Gorda", which was as head of the city of San Luis de la Paz. Once the territory was divided into two districts, five parties and ten municipalities, Mineral de Pozos (at that time Ciudad Porfirio Diaz) became part of the District and Party of San Luis la Paz, being one of the 9 municipalities.
Once this territory is fragmented, due to its high maintenance costs, Mineral de Pozos became part of the municipality of San Luis de la Paz in a definitive way.